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TIMECART

CPM’s TIMECART is a comprehensive product for the Tumor Immune Microenvironment (TME/TIME) characterization. It is an integrated platform consisting of a suite of tools and pipelines to characterize and analyse tumor microenvironment (TME) as well as tumor immune microenvironment/infiltration (TIME) from bulk expression data. It enables patient TME mapping and the study of patient's responses to treatments.

Data modalities: Clinical & Immunomics

Chrome

Objectives & outcomes:

    Patient-level analytics:
  • Immune and stromal cell population estimation for an individual patient
    Cohort-level analytics:
  • Quantification and analysis of immune-related signature scores
  • Identification of immune-related differentially expressed genes (IR-DEGs)
  • Immunomodulators and cytokine expression profiles
  • Immune-related pathway enrichment analysis
  • Prognostic immune signature (PIS) identification and patient stratification

Salient features:

  • Provides a single platform for characterizing the TME at the cellular and molecular level
  • Enables characterization of immune and stromal cell profiles for the individual patient
  • Allows quantification and identification of various immune-related signatures which have immunotherapeutic as well as prognostic significance
  • Helps in understanding tumor immunogenicity and its impact on treatment strategies, particularly in the case of immunotherapy

Demo use case: Breast cancer
Data source: The Cancer Genome Atlas
Business model: Contract services
Please write to us: for details & we will be happy to discuss: timecartbd@citadelpm.io